The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.

@article{Kottyan2015TheIA,
  title={The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.},
  author={Leah C. Kottyan and Erin E. Zoller and Jessica Bene and Xiaoming Lu and Jennifer A. Kelly and Andrew M. Rupert and Christopher J. Lessard and Samuel E. Vaughn and Miranda C. Marion and Matthew T. Weirauch and Bahram Namjou and Adam J. Adler and Astrid Rasmussen and Stuart B. Glenn and Courtney G. Montgomery and Gideon M. Hirschfield and Gang Xie and Catalina Coltescu and Christopher I. Amos and He Li and John A. Ice and Swapan K Nath and Xavier Mariette and Simon J. Bowman and Maureen Rischmueller and Susan Lester and Johan G Brun and Lasse Gunnar G{\o}ransson and E. G. Harboe and Roald Omdal and Deborah S. Cunninghame-Graham and Timothy J. Vyse and Corinne Miceli‐Richard and Michael T. Brennan and James A. Lessard and Marie Wahren-Herlenius and Marika Kvarnstr{\"o}m and Gabor G. Illei and Torsten Witte and Roland Jonsson and Per Eriksson and Gunnel Nordmark and Wan-Fai Ng and Juan-Manuel Anaya and Nelson L. Rhodus and Barbara M. Segal and Joan T. Merrill and Judith A James and Joel M Guthridge and Robert Hal Scofield and Marta E. Alarc{\'o}n-Riquelme and Sang-Cheol Bae and Susan A. Boackle and Lindsey A. Criswell and Gary Steven Gilkeson and Diane L. Kamen and Chaim O. Jacob and Robert P. Kimberly and Elizabeth E. Brown and Jeffrey C. Edberg and Graciela S Alarc{\'o}n and John D. Reveille and Luis M Vil{\'a} and Michelle A Petri and Rosalind Ramsey‐Goldman and Barry I. Freedman and Timothy B Niewold and Anne M. Stevens and Betty P Tsao and Jun Ying and Maureen D. Mayes and Olga Y. Gorlova and Ward Wakeland and Timothy R.D.J. Radstake and Ezequiel Mart{\'i}n and Javier Martin and Katherine A. Siminovitch and Kathy L. Moser Sivils and Patrick M Gaffney and Carl D. Langefeld and John B Harley and Kenneth M Kaufman},
  journal={Human molecular genetics},
  year={2015},
  volume={24 2},
  pages={
          582-96
        }
}
Key MethodExploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian and frequentist approaches to model the IRF5-TNPO3 locus association, now implicated in two immunotherapies and seven autoimmune diseases. Specifically, in systemic lupus erythematosus (SLE), we resolved separate associations in the IRF5 promoter (all ancestries) and with an extended European haplotype. We captured 3230 IRF5-TNPO3 high-quality, common variants across 5 ethnicities in 8395 SLE cases…Expand
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