The IRF family transcription factors at the interface of innate and adaptive immune responses.

@article{Ikushima2013TheIF,
  title={The IRF family transcription factors at the interface of innate and adaptive immune responses.},
  author={Hiroaki Ikushima and Hideo Negishi and T. Taniguchi},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2013},
  volume={78},
  pages={105-16}
}
The interferon-regulatory factor (IRF) family, originally identified as transcriptional regulators of the type I interferon system, consists of nine members in mammals. A large number of studies have revealed the versatile and critical functions performed by this transcription factor family in immunity and other biological processes. Most notably, the advances in the study of signal transducing innate immune receptors have placed many IRF members as central mediators in the regulation of innate… CONTINUE READING

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