The IP3 receptor/Ca2+ channel and its cellular function.

  title={The IP3 receptor/Ca2+ channel and its cellular function.},
  author={Katsuhiko Mikoshiba},
  journal={Biochemical Society symposium},
The IP3R [IP3 (inositol 1,4,5-trisphosphate) receptor] is responsible for Ca2+ release from the ER (endoplasmic reticulum). We have been working extensively on the P400 protein, which is deficient in Purkinje-neuron-degenerating mutant mice. We have discovered that P400 is an IP3R and we have determined the primary sequence. Purified IP3R, when incorporated into a lipid bilayer, works as a Ca2+ release channel and overexpression of IP3R shows enhanced IP3 binding and channel activity. Addition… CONTINUE READING