The INO2 and INO4 loci of Saccharomyces cerevisiae are pleiotropic regulatory genes.

@article{Loewy1984TheIA,
  title={The INO2 and INO4 loci of Saccharomyces cerevisiae are pleiotropic regulatory genes.},
  author={B S Loewy and Susan A Henry},
  journal={Molecular and cellular biology},
  year={1984},
  volume={4 11},
  pages={2479-85}
}
We isolated a mutant of Saccharomyces cerevisiae defective in the formation of phosphatidylcholine via methylation of phosphatidylethanolamine. The mutant synthesized phosphatidylcholine at a reduced rate and accumulated increased amounts of methylated phospholipid intermediates. It was also found to be auxotrophic for inositol and allelic to an existing series of ino4 mutants. The ino2 and ino4 mutants, originally isolated on the basis of an inositol requirement, are unable to derepress the… CONTINUE READING

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