The ING gene family in the regulation of cell growth and tumorigenesis.

@article{Coles2009TheIG,
  title={The ING gene family in the regulation of cell growth and tumorigenesis.},
  author={Andrew H. Coles and Stephen N. Jones},
  journal={Journal of cellular physiology},
  year={2009},
  volume={218 1},
  pages={45-57}
}
The five members of the inhibitor of growth (ING) gene family have garnered significant interest due to their putative roles as tumor suppressors. However, the precise role(s) of these ING proteins in regulating cell growth and tumorigenesis remains uncertain. Biochemical and molecular biological analysis has revealed that all ING members encode a PHD finger motif proposed to bind methylated histones and phosphoinosital, and all ING proteins have been found as components of large chromatin… CONTINUE READING