The IL23 axis plays a key role in the pathogenesis of IBD.

@article{McGovern2007TheIA,
  title={The IL23 axis plays a key role in the pathogenesis of IBD.},
  author={David J. McGovern and Fiona Powrie},
  journal={Gut},
  year={2007},
  volume={56 10},
  pages={
          1333-6
        }
}
Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD. 
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Cutting edge : IL23 crossregulates IL - 12 production in T celldependent experimental colitis

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