The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1.

@article{Carrol2011TheIP,
  title={The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1.},
  author={Enitan D Carrol and Antony Payton and Deborah Payne and F{\'a}bio Miyajima and Mas Chaponda and Limangeni A. Mankhambo and Daniel Lawadi Banda and Elizabeth Molyneux and Helen Cox and Greg Jacobson and Daniel F Carr and Malcolm Edward Molyneux and James P. Stewart and John P Quinn and Charles A. Hart and William E. R. Ollier},
  journal={Journal of immunology},
  year={2011},
  volume={186 4},
  pages={
          2329-35
        }
}
IL-1R antagonist (IL-1Ra) is required for adequate host defense in invasive pneumococcal disease (IPD). The minor allele of an IL1RN gene (C/T) promoter polymorphism (rs4251961) has been shown to be associated with decreased IL-1Ra production in healthy adults. We genotyped 299 children with IPD, and examined 19 IL1RN haplotype-tagging single-nucleotide polymorphisms. Human embryonic kidney HEK293(T) cells were transfected with the promoter reporter plasmid pGL3p containing either allelic… CONTINUE READING

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