The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation.

@article{Ye2001TheIR,
  title={The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation.},
  author={S. K. Ye and Yasutoshi Agata and Hin C. Lee and Hisanori Kurooka and Toshio Kitamura and Akira Shimizu and Tsuyoshi Honjo and Koichi Ikuta},
  journal={Immunity},
  year={2001},
  volume={15 5},
  pages={
          813-23
        }
}
The IL-7 receptor (IL-7R) plays critical roles in expansion and V(D)J recombination during lymphocyte development. Here we demonstrate that cytokine stimulation rapidly recruits Stat5 and transcriptional coactivators to the Jgamma germline promoter and induces histone acetylation, germline transcription, and accessibility in Ba/F3 cells. We also show that histone acetylation of the TCRgamma locus is significantly reduced in IL-7R-deficient thymocytes and that the introduction of active Stat5… CONTINUE READING
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