The IL-4R pathway in macrophages and its potential role in silica-induced pulmonary fibrosis

Abstract

Crystalline silica exposure can result in pulmonary fibrosis, where the pulmonary macrophage is key as a result of its ability to react to silica particles. In the mouse silicosis model, there is initial Th1-type inflammation, characterized by TNFand IFN. Previous studies determined that Th2 mediators (i.e., IL-13) are vital to development of pulmonary… (More)

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