The IL-33/ST2 pathway: therapeutic target and novel biomarker

@article{Kakkar2008TheIP,
  title={The IL-33/ST2 pathway: therapeutic target and novel biomarker},
  author={Rahul Kakkar and Richard T Lee},
  journal={Nature Reviews Drug Discovery},
  year={2008},
  volume={7},
  pages={827-840}
}
For many years, the interleukin-1 receptor family member ST2 was an orphan receptor that was studied in the context of inflammatory and autoimmune disease. However, in 2005, a new cytokine — interleukin-33 (IL-33) — was identified as a functional ligand for ST2. IL-33/ST2 signalling is involved in T-cell mediated immune responses, but more recently, an unanticipated role in cardiovascular disease has been demonstrated. IL-33/ST2 not only represents a promising cardiovascular biomarker but also… CONTINUE READING
Highly Influential
This paper has highly influenced 20 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 218 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 178 references

Complementary roles for biomarkers of biomechanical strain , ST 2 and NT ‐ proBNP , in patients with ST ‐ elevation myocardial infarction

  • M. S. Sabatine
  • Circulation
  • 2008

Complementary roles for biomarkers of biomechanical strain, ST2 and NTproBNP, in patients with ST-elevation myocardial infarction. Circulation

  • MS Sabatine
  • 2008

Similar Papers

Loading similar papers…