The IL-23 axis in Salmonella gastroenteritis.

  title={The IL-23 axis in Salmonella gastroenteritis.},
  author={Ivan Godinez and A. Marijke Keestra and Alanna M. Spees and Andreas J B{\"a}umler},
  journal={Cellular microbiology},
  volume={13 11},
Non-typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin-23 (IL-23)-dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL-23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.