The IL-23–IL-17 axis in inflammatory arthritis

  title={The IL-23–IL-17 axis in inflammatory arthritis},
  author={Erik Lubberts},
  journal={Nature Reviews Rheumatology},
The discovery that the IL-23–IL-17 immune pathway is involved in many models of autoimmune disease has changed the concept of the role of T-helper cell subsets in the development of autoimmunity. In addition to TH17 cells, IL-17 is also produced by other T cell subsets and innate immune cells; which of these IL-17-producing cells have a role in tissue inflammation, and the timing, location and nature of their role(s), is incompletely understood. The current view is that innate and adaptive… CONTINUE READING
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