The IL-17 cytokine family.

  title={The IL-17 cytokine family.},
  author={Sarah L Gaffen and Jill M. Kramer and Jeffrey Yu and Fang Shen},
  journal={Vitamins and hormones},
IL-17A and its receptor are the founding members of a recently described cytokine family, with unique sequences and functions in the immune system and elsewhere. Consisting of six ligands (IL-17A-F) and five receptors (IL-17RA-IL-17RE) in mammals, these molecules have distinct primary amino acid structures with only minimal homology to other cytokine families. By far the best studied of these cytokines to date are IL-17A and its receptor, IL-17RA. IL-17A is produced primarily by T cells, and is… CONTINUE READING


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