The IL-1 type 1 receptor is required for the development of LPS-induced airways disease.

BACKGROUND The contribution of IL-1beta signaling through the IL-1 type 1 receptor (IL-1R1) to the development of persistent LPS-induced airway disease has not been investigated. OBJECTIVE To determine the importance of signaling through the IL-1 type 1 receptor in the development of LPS-induced airway disease. METHODS We exposed IL-1R1-deficient (C57BL… CONTINUE READING