The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

@inproceedings{Borthwick2016TheIC,
  title={The IL-1 cytokine family and its role in inflammation and fibrosis in the lung},
  author={Lee A. Borthwick},
  booktitle={Seminars in Immunopathology},
  year={2016}
}
The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of inflammation and fibrosis in multiple tissues including the lung. IL-1 targeted therapies have been successfully employed to treat a range of inflammatory conditions such as rheumatoid arthritis and gouty arthritis. This review will introduce the members of the IL-1 cytokine family, briefly discuss the cellular origins… CONTINUE READING

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