The IL‐17 pathway as a major therapeutic target in autoimmune diseases

@article{Hu2011TheIP,
  title={The IL‐17 pathway as a major therapeutic target in autoimmune diseases},
  author={Yan Hu and F. Shen and N. Crellin and W. Ouyang},
  journal={Annals of the New York Academy of Sciences},
  year={2011},
  volume={1217}
}
Th17 cells are a subset of T helper cells that have been recently found to play important functions in host defense and the pathogenesis of various human autoimmune and inflammatory diseases. Th17 cells produce IL‐17A, IL‐17F, IL‐22, and IL‐21, of which IL‐17A and IL‐17F mediate many of the downstream pathologic functions of these cells. IL‐17A and IL‐17F signal through IL‐17RA and IL‐17RC heterodimeric receptors that are mainly expressed on tissue epithelial cells and fibroblasts. While IL‐17A… Expand
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