The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis.

@article{Liu2013TheII,
  title={The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis.},
  author={Mingzhu Liu and Anna Roth and Min Yu and Robert Morris and Francesca Bersani and Miguel N. Rivera and Jun Lu and Toshihiro Shioda and Shobha Vasudevan and Sridhar Ramaswamy and S. Maheswaran and Sven Diederichs and Daniel A. Haber},
  journal={Genes & development},
  year={2013},
  volume={27 23},
  pages={2543-8}
}
Insulin-like growth factor 2 (IGF2), a developmentally regulated and maternally imprinted gene, is frequently overexpressed in pediatric cancers. Although loss of imprinting (LOI) at fetal promoters contributes to increased IGF2 in tumors, the magnitude of IGF2 expression suggests the involvement of additional regulatory mechanisms. A microRNA (miRNA) screen of primary Wilms' tumors identified specific overexpression of miR-483-5p, which is embedded within the IGF2 gene. Unexpectedly, the IGF2… CONTINUE READING