The IGF system in thyroid cancer: new concepts.

@article{Vella2001TheIS,
  title={The IGF system in thyroid cancer: new concepts.},
  author={Veronica Vella and Laura Sciacca and G Pandini and Rossana Mineo and Sebastiano Squatrito and Riccardo Vigneri and Antonio Belfiore},
  journal={Molecular pathology : MP},
  year={2001},
  volume={54 3},
  pages={
          121-4
        }
}
In recent years, the activation of the insulin-like growth factor (IGF) system in cancer has emerged as a key factor for tumour progression and resistance to apoptosis. Therefore, a variety of strategies have been developed to block the type I IGF receptor (IGF-I-R), which is thought to mediate the biological effects of both IGF-I and IGF-II. However, recent data suggest that the IGF signalling system is complex and that other receptors are involved. To unravel the complexity of the IGF system… CONTINUE READING

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