The ICAM-1 antisense oligonucleotide ISIS-3082 prevents the development of postoperative ileus in mice.

@article{The2005TheIA,
  title={The ICAM-1 antisense oligonucleotide ISIS-3082 prevents the development of postoperative ileus in mice.},
  author={Frans O The and Wouter J. de Jonge and Roel J. Bennink and R M van den Wijngaard and Guy E. E. Boeckxstaens},
  journal={British journal of pharmacology},
  year={2005},
  volume={146 2},
  pages={252-8}
}
Intestinal manipulation (IM) during abdominal surgery triggers the influx of inflammatory cells, leading to postoperative ileus. Prevention of this local muscle inflammation, using intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antigen-1-specific antibodies, has been shown to shorten postoperative ileus. However, the therapeutic use of antibodies has considerable disadvantages. The aim of the current study was to evaluate the effect of ISIS-3082, a mouse-specific… CONTINUE READING

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