The IBD International Genetics Consortium Provides Further Evidence for Linkage to IBD4 and Shows Gene‐Environment Interaction

@article{Pierik2005TheII,
  title={The IBD International Genetics Consortium Provides Further Evidence for Linkage to IBD4 and Shows Gene‐Environment Interaction},
  author={Marie J Pierik and Huiying Yang and M. Michael Barmada and Juleen A. Cavanaugh and Vito Annese and Steven R. Brant and Judy H. Cho and Richard H. Duerr and Jean-Pierre Hugot and Dermot P. B. McGovern and Paulina Paavola-Sakki and Graham L. Radford-Smith and Paul Pavli and Mark S. Silverberg and S Schreiber and Kent D. Taylor and Robert F. Vlietinck},
  journal={Inflammatory Bowel Diseases},
  year={2005},
  volume={11},
  pages={1–7}
}
Background and Aims: The inflammatory bowel diseases (IBDs) Crohn's disease (CD) and ulcerative colitis are complex disorders with an important genetic determinant. One gene associated with CD has been identified: NOD2/CARD15. Two independent genome‐wide scans found significant evidence (logarithm of odds [LOD] 3.6) and suggestive evidence (LOD 2.8) for linkage on locus 14q11‐12, also known as the IBD4 locus. To further characterize this locus, we assessed gene‐environment interaction (IBD4… 
Inflammatory bowel disease genetics: Nod2.
TLDR
Taken together, the Nod2 association to CD provides an illustrative model of the role of single gene variants in disease pathogenesis for common, complex multigenic disorders.
Role of genes, the environment and their interactions in the etiology of inflammatory bowel diseases
  • F. Ahmed
  • Medicine, Biology
    Expert review of molecular diagnostics
  • 2006
TLDR
Animal models must be further studied to explore mechanistic interactions of the role of genetics and environmental contribution to the etiopathology of IBD, as transgenic or knockout mice, such as interleukin-10-/-, T-cell receptor α-/- and N-cadherin-/- develop colitis-like inflammation similar to humans.
Genetics of Inflammatory Bowel Diseases
TLDR
As the knowledge of genotype–phenotype associations grows, it is anticipated that genotyping at the onset of disease may enable physicians to predict disease course and tailor medical therapies specific for each patient.
Immunogenetic biomarkers in inflammatory bowel diseases: role of the IBD3 region.
TLDR
Recent insights into the biological function of other genes encoded within the IBD3 region, such as the MHC class I chain-related (MIC) genes, have led investigators to a more comprehensive exploration of this region.
Frequency of single nucleotide polymorphisms in NOD1 gene of ulcerative colitis patients: a case-control study in the Indian population
TLDR
It is proposed that the location of mutations in the Exon 6 spanning the ATP and Mg2+ binding site of NBD in NOD1 gene may affect the process of oligomerization and subsequent function of the LRR domain.
Genetics of Inflammatory Bowel Diseases.
TLDR
The rapidly evolving area of direct-to-consumer genetic testing and the current utility of clinical exome sequencing is discussed, especially in very early onset, severe IBD cases.
Genetic Evidence Supporting the Association of Protease and Protease Inhibitor Genes with Inflammatory Bowel Disease: A Systematic Review
TLDR
A computer algorithm is developed to map the 807 P/PI genes with exact genomic locations listed in the MEROPS database of peptidases onto these critical regions and to rank P/ PI genes according to the accumulated evidence for their association with Crohn's disease and UC.
Heritability in Inflammatory Bowel Disease: From the First Twin Study to Genome-Wide Association Studies
TLDR
Twin and family studies continue to support a strong genetic basis of the inflammatory bowel diseases and further work aimed at quantifying the variance explained across GWAS, epigenome-wide, and microbiota-wide association studies will help to define factors leading to inflammatory bowel disease.
Recent advances in the genetics of inflammatory bowel disease
TLDR
The article discusses current information on the relation between CARD15 variants and Crohn disease and the discoveries of SLC22A4/SLC 22A5 and DLG5 gene variants that also confer risk for inflammatory bowel disease.
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