The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease.

@article{Ernsberger1997TheIR,
  title={The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease.},
  author={Paul R Ernsberger and Jacob E. Friedman and Richard J. Koletsky},
  journal={Journal of hypertension. Supplement : official journal of the International Society of Hypertension},
  year={1997},
  volume={15 1},
  pages={S9-23}
}
OBJECTIVE To review previous work and present additional evidence characterizing the I1-imidazoline receptor and its role in cellular signaling, central cardiovascular control, and the treatment of metabolic syndromes. Second-generation centrally-acting antihypertensives inhibit sympathetic activity mainly via imidazoline receptors, whereas first-generation agents act via alpha2-adrenergic receptors. The I1 subtype of imidazoline receptor resides in the plasma membrane and binds central… CONTINUE READING

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