The I1-imidazoline-binding site is a functional receptor mediating vasodepression via the ventral medulla.

@article{Ernsberger1997TheIS,
  title={The I1-imidazoline-binding site is a functional receptor mediating vasodepression via the ventral medulla.},
  author={Paul R Ernsberger and Musa A. Haxhiu},
  journal={The American journal of physiology},
  year={1997},
  volume={273 5 Pt 2},
  pages={R1572-9}
}
I1-imidazoline-binding sites fulfill all essential criteria for identification as receptors, including specificity of binding, association with physiological functions, appropriate anatomic and cellular and subcellular localization, and specific cell signaling pathways. Moreover, binding affinities correlate with functional drug responses. The evidence linking I1 receptors to vasodepression includes expression in RVLM and consistent correlations between vasodepressor potency in humans and… CONTINUE READING
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