The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection.

@article{Jobin2000TheIK,
  title={The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection.},
  author={Christian Jobin and Ryan Balfour Sartor},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={278 3},
  pages={C451-62}
}
The ubiquitous transcription factor NF-kappa B is a central regulator of the transcriptional activation of a number of genes involved in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. Induction of these genes in intestinal epithelial cells (IECs) by activated NF-kappa B profoundly influences mucosal inflammation and repair. NF-kappa B activation requires the removal of I kappa B from NF-kappa B by inducible proteolysis, which liberates this… CONTINUE READING

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