The I-TASSER Suite: protein structure and function prediction

  title={The I-TASSER Suite: protein structure and function prediction},
  author={Jianyi Yang and Renxiang Yan and Ambrish Roy and Dong Xu and Jonathan Poisson and Yang Arthur Zhang},
  journal={Nature Methods},
The lowest free-energy conformations are identified by structure clustering. A second round of assembly simulation is conducted, starting from the centroid models, to remove steric clashes and refine global topology. Final atomic structure models are constructed from the low-energy conformations by a two-step atomic-level energy minimization approach. The correctness of the global model is assessed by the confidence score, which is based on the significance of threading alignments and the… CONTINUE READING
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