The IκB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus 

@article{Merlo2002TheIK,
  title={The I$\kappa$B kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus
},
  author={Emiliano Merlo and Ramiro Freudenthal and Arturo Romano},
  journal={Neuroscience},
  year={2002},
  volume={112},
  pages={161-172}
}
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101 Citations

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Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus
Phosphorylation of extra-nuclear ERK/MAPK is required for long-term memory consolidation in the crab Chasmagnathus
Activation of the transcription factor NF-kappaB by retrieval is required for long-term memory reconsolidation.
TLDR
Findings indicate for the first time that NF-kappaB is activated specifically by retrieval and that this activation is required for memory reconsolidation, supporting the view that this molecular mechanism is required in both consolidation and reconsolidations.
ONG-TERM MEMORY CONSOLIDATION DEPENDS ON PROTEASOME CTIVITY IN THE CRAB CHASMAGNATHUS
  • Biology
  • 2007
TLDR
It is suggested that the PS is necessary for long-term memory consolidation and for the activation of NFB as one of the target molecular athways.
Activation of Hippocampal Nuclear Factor-κB by Retrieval Is Required for Memory Reconsolidation
TLDR
It is demonstrated that the inhibition of NF-κB after memory reactivation impairs retention of a hippocampal-dependent inhibitory avoidance task in mice, and results indicate that NF-σB is an important transcriptional regulator in memory consolidation and reconsolidation in hippocampus, although the temporal kinetics of activation differs between the two processes.
Acetylation of nuclear factor-kappaB in rat amygdala improves long-term but not short-term retention of fear memory.
TLDR
Evidence is provided that HDAC-mediated deacetylation functions as an intranuclear molecular switch culminating in the termination of NF-kappaB transcriptional response that is involved in the formation of fear memory.
NF-κB transcription factor role in consolidation and reconsolidation of persistent memories
TLDR
A review of experimental work obtained in the last years showing the essential role of the nuclear factor κB (NF-κB) family of transcription factors in memory processes in different learning tasks in mammals and on the regulation of immediate-early and late genes by epigenetic mechanisms that determine enduring forms of memories.
Roles for NF-κB and Gene Targets of NF-κB in Synaptic Plasticity, Memory, and Navigation
TLDR
There is ample evidence to suggest a critical role for NF-κB in memory, but understanding of its gene targets in neurons is limited and only beginning to be appreciated, so this review will synthesize the research evaluating gene targets of NF-σB in synaptic plasticity and memory.
Roles for NF-κB in Regulating Gene Expression in Synaptic Plasticity and Memory
TLDR
Previous studies have shown roles for some of these proteins in CNS disorders, where a rapidly growing literature supports the involvement of NF-κB, not only in neurodegenerative conditions, but also in synaptic plasticity and memory.
Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: Control on nuclear factor‐κB signaling in consolidation and reconsolidation
TLDR
A novel mechanism by which memory formation and reprocessing can be controlled by CaN regulation on NF‐κB activity is supported, suggesting that reinforcement during reconsolidation is more persistent than during consolidation.
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References

SHOWING 1-10 OF 47 REFERENCES
Participation of Rel/NF-κB transcription factors in long-term memory in the crab Chasmagnathus
Two Critical Periods for cAMP-Dependent Protein Kinase Activity during Long-Term Memory Consolidation in the Crab Chasmagnathus
TLDR
Two phases of PKA activity are required during consolidation of LTM, one during training and the other between 4 and 8 h after training, suggesting that in this type of memory PKA activation is not required.
Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.
TLDR
It is demonstrated that sulfasalazine is a potent and specific inhibitor of NF-kappaB activation, and thus may explain some of the known biological properties of sulf asalazine.
Suppression of NF-κB activity by sulfasalazine is mediated by direct inhibition of IκB kinases α and β
TLDR
Sulfasalazine is identified as a direct inhibitor of IKK-α and -β by antagonizing adenosine triphosphate binding and contributes to the well-known anti-inflammatory and immunosuppressive effects of sulfasalazines.
κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
A neuromodulatory role of interleukin-1β in the hippocampus
TLDR
It is shown for the first time that the production of biologically significant amounts of IL-1β in the brain can be induced by a sustained increase in the activity of a discrete population of neurons and a physiological involvement of this cytokine in synaptic plasticity is suggested.
Cycloheximide inhibits context memory and long-term habituation in the crab Chasmagnathus
Prostaglandins play a role in memory consolidation in the chick.
  • C. Hölscher
  • Biology, Psychology
    European journal of pharmacology
  • 1995
Brain synapses contain inducible forms of the transcription factor NF-κB
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