The IκB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus

@article{Merlo2002TheIK,
  title={The I$\kappa$B kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus
},
  author={Emiliano Merlo and Ramiro Freudenthal and Arturo Romano},
  journal={Neuroscience},
  year={2002},
  volume={112},
  pages={161-172}
}
Activation of the transcription factor NF-kappaB by retrieval is required for long-term memory reconsolidation.
TLDR
Findings indicate for the first time that NF-kappaB is activated specifically by retrieval and that this activation is required for memory reconsolidation, supporting the view that this molecular mechanism is required in both consolidation and reconsolidations.
ONG-TERM MEMORY CONSOLIDATION DEPENDS ON PROTEASOME CTIVITY IN THE CRAB CHASMAGNATHUS
  • Biology
  • 2007
TLDR
It is suggested that the PS is necessary for long-term memory consolidation and for the activation of NFB as one of the target molecular athways.
Activation of Hippocampal Nuclear Factor-κB by Retrieval Is Required for Memory Reconsolidation
TLDR
It is demonstrated that the inhibition of NF-κB after memory reactivation impairs retention of a hippocampal-dependent inhibitory avoidance task in mice, and results indicate that NF-σB is an important transcriptional regulator in memory consolidation and reconsolidation in hippocampus, although the temporal kinetics of activation differs between the two processes.
Acetylation of nuclear factor-kappaB in rat amygdala improves long-term but not short-term retention of fear memory.
TLDR
Evidence is provided that HDAC-mediated deacetylation functions as an intranuclear molecular switch culminating in the termination of NF-kappaB transcriptional response that is involved in the formation of fear memory.
NF-κB transcription factor role in consolidation and reconsolidation of persistent memories
TLDR
A review of experimental work obtained in the last years showing the essential role of the nuclear factor κB (NF-κB) family of transcription factors in memory processes in different learning tasks in mammals and on the regulation of immediate-early and late genes by epigenetic mechanisms that determine enduring forms of memories.
Roles for NF-κB and Gene Targets of NF-κB in Synaptic Plasticity, Memory, and Navigation
TLDR
There is ample evidence to suggest a critical role for NF-κB in memory, but understanding of its gene targets in neurons is limited and only beginning to be appreciated, so this review will synthesize the research evaluating gene targets of NF-σB in synaptic plasticity and memory.
Roles for NF-κB in Regulating Gene Expression in Synaptic Plasticity and Memory
TLDR
Previous studies have shown roles for some of these proteins in CNS disorders, where a rapidly growing literature supports the involvement of NF-κB, not only in neurodegenerative conditions, but also in synaptic plasticity and memory.
Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: Control on nuclear factor‐κB signaling in consolidation and reconsolidation
TLDR
A novel mechanism by which memory formation and reprocessing can be controlled by CaN regulation on NF‐κB activity is supported, suggesting that reinforcement during reconsolidation is more persistent than during consolidation.
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