The Hypotensive Action of Rilmenidine is Dependent on FunctionalN-Methyl-d-aspartate Receptor in the Rostral Ventrolateral Medulla of Conscious Spontaneously Hypertensive Rats

@article{Zhang2002TheHA,
  title={The Hypotensive Action of Rilmenidine is Dependent on FunctionalN-Methyl-d-aspartate Receptor in the Rostral Ventrolateral Medulla of Conscious Spontaneously Hypertensive Rats},
  author={Jian Zhang and Abdel A. Abdel‐Rahman},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2002},
  volume={303},
  pages={204 - 210}
}
Rilmenidine is a second-generation centrally acting antihypertensive drug that acts mainly through the activation of the imidazoline (I1) receptor in the rostral ventrolateral medulla (RVLM). To investigate the contribution of theN-methyl-d-aspartate receptor (NMDAR) to the hypotensive action of rilmenidine, experiments were undertaken in conscious male spontaneously hypertensive rats (SHRs). Microinjection of cumulative doses of rilmenidine (10, 20, and 40 nmol) at 10- to 15-min intervals… 
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Data show that blockade of AMPA/kainate receptors in the RVLM significantly antagonizes decreases in BP, HR, and sympathetic activity induced by clonidine, suggesting that the AMPA-kainates receptors within the RV LM contribute to the depressor and sympathoinhibitory effect of clonacid.
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TLDR
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TLDR
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The role of NMDA and non-NMDA receptors in the NTS in mediating three distinct sympathoinhibitory reflexes
TLDR
The results suggest that while there is overlap in the area of the NTS responsible for eliciting all three reflexes, NMDA and non-NMDA receptors are recruited differentially for the full expression of these reflexes.
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References

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