The Hybrid Incompatibility Genes Lhr and Hmr Are Required for Sister Chromatid Detachment During Anaphase but Not for Centromere Function.

@article{Blum2017TheHI,
  title={The Hybrid Incompatibility Genes Lhr and Hmr Are Required for Sister Chromatid Detachment During Anaphase but Not for Centromere Function.},
  author={Jacob A. Blum and Silvia Bonaccorsi and Marta Marzullo and Valeria Palumbo and Yukiko M Yamashita and Daniel A. Barbash and Maurizio Gatti},
  journal={Genetics},
  year={2017},
  volume={207 4},
  pages={
          1457-1472
        }
}
Crosses between Drosophila melanogaster females and Drosophila simulans males produce hybrid sons that die at the larval stage. This hybrid lethality is suppressed by loss-of-function mutations in the D. melanogaster Hybrid male rescue (Hmr) or in the D. simulans Lethal hybrid rescue (Lhr) genes. Previous studies have shown that Hmr and Lhr interact with heterochromatin proteins and suppress expression of transposable elements within D. melanogaster It also has been proposed that Hmr and Lhr… CONTINUE READING
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