The Huntington's disease candidate region exhibits many different haplotypes

@article{MacDonald1992TheHD,
  title={The Huntington's disease candidate region exhibits many different haplotypes},
  author={M. MacDonald and A. Novelletto and Carol S. Lin and D. Tagle and G. Barnes and G. Bates and Sherryl A. M. Taylor and B. Allitto and M. Altherr and R. Myers and H. Lehrach and F. Collins and J. Wasmuth and M. Frontali and J. Gusella},
  journal={Nature Genetics},
  year={1992},
  volume={1},
  pages={99-103}
}
Analysis of 78 Huntington's disease (HD) chromosomes with multi–allele markers revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The most frequent haplotype, accounting for about one third of disease chromosomes, suggests that the disease gene is between D4S182 and D4S180. However, the paucity of an expected class of chromosomes that can be related to this major haplotype by assuming single crossovers may reflect the operation of other mechanisms in creating… Expand
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