The Hunt for Cyclin

  title={The Hunt for Cyclin},
  author={Peter K. Jackson and Peter Jackson},

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Cell cycle checkpoint control: The cyclin G1/Mdm2/p53 axis emerges as a strategic target for broad-spectrum cancer gene therapy - A review of molecular mechanisms for oncologists
A unifying model is presented that clarifies the function of cyclin G1 in establishing proliferative competence, overriding p53 checkpoints and advancing cell cycle progression and provides a mechanistic basis for understanding the broad-spectrum anticancer activity and single-agent efficacy observed with dominant-negative cyclinG1, whose cytocidal mechanism of action triggers programmed cell death.
A New Ultradian Rhythm Linked to Protein Degradation and Synthesis in Mammalian Cells
A new ultradian rhythm that occurs during the interphase of the cell cycle in a wide range of mammalian cells, including both primary and transformed cells is described, suggesting that it represents the periodic dynamics of protein mass in growing cells.
A new ultradian rhythm in mammalian cell dry mass observed by holography
It is shown that the amplitude of the fundamental frequency provides a way to quantify the effects of, chemical reagents on cells, thus shedding light on its mechanism and representing a massive degradation and re-synthesis of protein every 4 h in growing cells.
Genetic and biochemical evaluation of natural rubber from Eastern Washington prickly lettuce (Lactuca serriola L.).
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The B-Type Cyclin CYCB1-1 Regulates Embryonic Development and Seed Size in Maize
  • Bingbing Zhao, Miaoyi Zhou, Haohua He
  • International Journal of Molecular Sciences
  • 2022
Progress through the cell cycle is a critical process during plant embryo and seed development and its progression is regulated by cyclins. Despite extensive study of cyclins in other systems, their


NOBEL LECTURE: Protein Synthesis, Proteolysis, and Cell Cycle Transitions
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  • Biology
    Bioscience reports
  • 2002
The discovery of the role(s) of protein synthesis and degradation in the operation of the cell cycle is described.
NOBEL LECTURE: Cyclin Dependent Kinases and Cell Cycle Control
The discovery of major regulators of the eukaryotic cell cycle is described and the role of these regulators is described in maintaining the integrity of the cell cycle.
The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in
Cyclin is degraded by the ubiquitin pathway
Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle, and anaphase may be triggered by the recognition of cyclin by the ubiquitin-conjugating system.
Cyclin synthesis drives the early embryonic cell cycle
We have produced extracts of frog eggs that can perform multiple cell cycles in vitro. Destruction of the endogenous messenger RNA arrests the extracts in interphase. The addition of exogenous cyclin
The anaphase promoting complex/cyclosome: a machine designed to destroy
  • J. Peters
  • Biology
    Nature Reviews Molecular Cell Biology
  • 2006
Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.
Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.
During cell cycles 2-7, Cdc2/Cyclin complexes are continuously present and show little fluctuation in abundance, phosphomodification, or activity, which suggests that cycling of the mitotic apparatus does not require cytoplasmic oscillations of known regulatory activities.
The role of the destruction box and its neighbouring lysine residues in cyclin B for anaphase ubiquitin‐dependent proteolysis in fission yeast: defining the D‐box receptor
The K0‐N70 construct was neither polyubiquitinated nor degraded in vitro, but it blocked the growth of strains of yeast in which anaphase‐promoting complex/cyclosome function was compromised by mutation, and specifically inhibited proteolysis of APC/C substrates in vivo.