The Human Transcription Factors

@article{Lambert2018TheHT,
  title={The Human Transcription Factors},
  author={S. Lambert and A. Jolma and Laura F. Campitelli and P. Das and M. Weirauch},
  journal={Cell},
  year={2018},
  volume={172},
  pages={650-665}
}
Transcription factors (TFs) recognize specific DNA sequences to control chromatin and transcription, forming a complex system that guides expression of the genome. Despite keen interest in understanding how TFs control gene expression, it remains challenging to determine how the precise genomic binding sites of TFs are specified and how TF binding ultimately relates to regulation of transcription. This review considers how TFs are identified and functionally characterized, principally through… Expand
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