The Human Striatum is Necessary for Responding to Changes in Stimulus Relevance

@article{Cools2006TheHS,
  title={The Human Striatum is Necessary for Responding to Changes in Stimulus Relevance},
  author={Ronald Cools and Richard B. Ivry and Mark D'Esposito},
  journal={Journal of Cognitive Neuroscience},
  year={2006},
  volume={18},
  pages={1973-1983}
}
Various lines of evidence suggest that the striatum is implicated in cognitive flexibility. The neuropsychological evidence has, for the most part, been based on research with patients with Parkinson's disease, which is accompanied by chemical disruption of both the striatum and the prefrontal cortex. The present study examined this issue by testing patients with focal lesions of the striatum on a task measuring two forms of cognitive switching. Patients with striatal, but not frontal lobe… CONTINUE READING

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