The Human Rho-GEF Trio and Its Target GTPase RhoG Are Involved in the NGF Pathway, Leading to Neurite Outgrowth
@article{Estrach2002TheHR, title={The Human Rho-GEF Trio and Its Target GTPase RhoG Are Involved in the NGF Pathway, Leading to Neurite Outgrowth}, author={Soline Estrach and Susanne Schmidt and Sylvie Diriong and Aubin Penna and Anne Blangy and Philippe Fort and Anne Debant}, journal={Current Biology}, year={2002}, volume={12}, pages={307-312} }
151 Citations
GEFT, A Rho Family Guanine Nucleotide Exchange Factor, Regulates Neurite Outgrowth and Dendritic Spine Formation*
- BiologyJournal of Biological Chemistry
- 2004
The data suggest that GEFT enhances dendritic spine formation and neurite outgrowth in primary neurons and neuroblastoma cells, respectively, through the activation of Rac/Cdc42-PAK signaling pathways.
Kidins220/ARMS regulates Rac1-dependent neurite outgrowth by direct interaction with the RhoGEF Trio
- BiologyJournal of Cell Science
- 2010
The data indicate that Kidins220 might localise Trio to specific membrane sites and regulate its activity, leading to Rac1 activation and neurite outgrowth.
Tyrosine Phosphorylation of the Rho Guanine Nucleotide Exchange Factor Trio Regulates Netrin-1/DCC-Mediated Cortical Axon Outgrowth
- BiologyMolecular and Cellular Biology
- 2012
It is demonstrated that TrioY2622 phosphorylation is essential for the regulation of the DCC/Trio signaling complex in cortical neurons during netrin-1-mediated axon outgrowth.
RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo
- Biology, ChemistryNature
- 2003
It is shown that RhoG activates Rac1 through Elmo and Dock180 to control cell morphology and interacts directly with Elmo in a GTP-dependent manner and forms a ternary complex with Dock 180 to induce activation of Rac1.
Dynamic Microtubules Catalyze Formation of Navigator-TRIO Complexes to Regulate Neurite Extension
- BiologyCurrent Biology
- 2014
Identification of the first Rho–GEF inhibitor, TRIPα, which targets the RhoA‐specific GEF domain of Trio
- Biology, ChemistryFEBS letters
- 2002
RhoG regulates gene expression and the actin cytoskeleton in lymphocytes
- BiologyOncogene
- 2003
Using effector domain mutants of RhoG, it is found that its ability to potentiate NFAT-dependent transcription correlates with its capacity to increase actin polymerization, supporting the suggestion that NFAT -dependent transcription is an actin-dependent process.
Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC‐induced dendritic tree complexity
- BiologyJournal of neurochemistry
- 2016
The roles of the small GTPases Rac1, Cdc42, and RhoG in defining dendritic tree complexity stimulated by the transmembrane epidermal growth factor family member CALEB/NGC are investigated.
miR‐124‐regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling
- BiologyThe EMBO journal
- 2012
RhoG emerges as a cellular conductor of Rac1 and Cdc42 activity, in turn regulated by miR‐124 to control axonal and dendritic branching.
A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway.
- Biology, ChemistryChemistry & biology
- 2009
References
SHOWING 1-10 OF 22 REFERENCES
TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG.
- BiologyJournal of cell science
- 2000
It is demonstrated that Trio controls a signaling cascade that activates RhoG, which in turn activates Rac1 and Cdc42Hs, which strongly supports Rac1 not being activated by TrioD1 in vivo.
Small GTPase RhoG Is a Key Regulator for Neurite Outgrowth in PC12 Cells
- BiologyMolecular and Cellular Biology
- 2000
It is suggested that RhoG is a key regulator in NGF-induced neurite outgrowth, acting downstream of Ras and upstream of Rac1 and Cdc42 in PC12 cells.
The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo
- BiologyOncogene
- 1998
Trio represents a unique member of the Rho-GEFs family possessing two functional domains of distinct specificities, that allow it to link Rho and Rac signaling pathway in vivo.
RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs.
- BiologyMolecular biology of the cell
- 1998
The data demonstrate that RhoG controls a pathway that requires the microtubule network and activates Rac1 and Cdc42Hs independently of their growth factor signaling pathways.
Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid.
- Biology, ChemistryMolecular and cellular biology
- 1997
There is competition between the ACh- and LPA-induced morphological pathways mediated by Cdc42Hs and/or Rac1 and by RhoA, leading to either neurite development or collapse in N1E-115 neuroblastoma growth cones.
UNC-73 Activates the Rac GTPase and Is Required for Cell and Growth Cone Migrations in C. elegans
- BiologyCell
- 1998
The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.
- Biology, ChemistryProceedings of the National Academy of Sciences of the United States of America
- 1996
As the LAR PTPase localizes to the ends of focal adhesions, it is proposed that LAR and the Trio GEF/PSK may orchestrate cell-matrix and cytoskeletal rearrangements necessary for cell migration.
Dosage-Sensitive, Reciprocal Genetic Interactions between the Abl Tyrosine Kinase and the Putative GEF trio Reveal trio's Role in Axon Pathfinding
- BiologyNeuron
- 2000
Kinectin Is a Key Effector of RhoG Microtubule-Dependent Cellular Activity
- Biology, ChemistryMolecular and Cellular Biology
- 2001
The functional links among RhoG, kinectin, and kinesin are further supported by time-lapse videomicroscopy of COS-7 cells, which showed that the microtubule-dependent lysosomal transport is facilitated by RhoRhoG activation orKinectin overexpression and is severely stemmed upon RHoG inhibition.
The DH protein family, exchange factors for Rho-like GTPases.
- Biology, ChemistryProgress in molecular and subcellular biology
- 1999
Members of the Ras superfamily of GTPases play critical roles in regulating a wide range of cellular processes, including growth, differentiation, various forms of vesicle transport, nuclear…