The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells

@article{Elphick2004TheHP,
  title={The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells},
  author={Gwendolyn F. Elphick and W. Querbes and Joslynn A Jordan and G. V. Gee and S. Eash and K. Manley and A. Dugan and Megan L. Stanifer and A. Bhatnagar and W. K. Kroeze and B. Roth and W. Atwood},
  journal={Science},
  year={2004},
  volume={306},
  pages={1380 - 1383}
}
  • Gwendolyn F. Elphick, W. Querbes, +9 authors W. Atwood
  • Published 2004
  • Medicine, Biology
  • Science
  • The human polyomavirus, JCV, causes the fatal demyelinating disease progressive multifocal leukoencephalopathy in immunocompromised patients. We found that the serotonergic receptor 5HT2AR could act as the cellular receptor for JCV on human glial cells. The 5HT2A receptor antagonists inhibited JCV infection, and monoclonal antibodies directed at 5HT2A receptors blocked infection of glial cells by JCV, but not by SV40. Transfection of 5HT2A receptor–negative HeLa cells with a 5HT2A receptor… CONTINUE READING

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