The Human Mitochondrial Transcriptome

  title={The Human Mitochondrial Transcriptome},
  author={Tim R. Mercer and Shane J. Neph and Marcel E. Dinger and Joanna Crawford and Martin A. Smith and Anne-Marie J. Shearwood and Eric Haugen and Cameron P. Bracken and Oliver Rackham and John A. Stamatoyannopoulos and Aleksandra Filipovska and John S. Mattick},
The human mitochondrial genome comprises a distinct genetic system transcribed as precursor polycistronic transcripts that are subsequently cleaved to generate individual mRNAs, tRNAs, and rRNAs. Here, we provide a comprehensive analysis of the human mitochondrial transcriptome across multiple cell lines and tissues. Using directional deep sequencing and parallel analysis of RNA ends, we demonstrate wide variation in mitochondrial transcript abundance and precisely resolve transcript processing… CONTINUE READING
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