The Human Microbiome: Getting Personal: Each of us harbors a unique microbiome, and its characteristics play an important role in differentiating us from one another
@article{Califf2014TheHM, title={The Human Microbiome: Getting Personal: Each of us harbors a unique microbiome, and its characteristics play an important role in differentiating us from one another}, author={Katy J. Califf and Antonio Gonzalez and Rob Knight and J. Gregory Caporaso}, journal={Microbe Magazine}, year={2014}, volume={9}, pages={410-415} }
Through reliance on DNA sequencing and associated bioinformatics techniques, we are vastly expanding our understanding of the human microbiome. Each of us harbors a unique microbiome, and its characteristics play an important role in differentiating us from one another. Our microbes contribute to many aspects of our health and our lives, including our metabolism of food, whether we develop cancer, how we behave, and how we respond to medical treatments.
14 Citations
The Oral Microbiome in Health and Disease
- Biology
- 2016
The architecture of biofilms in periodontitis and caries is visualized and the knowledge on the oral microbiota challenges the current practice of chairside diagnostics.
Geography and Location Are the Primary Drivers of Office Microbiome Composition
- Environmental SciencemSystems
- 2016
A study on the impacts of geography, material type, human interaction, location in a room, seasonal variation, and indoor and microenvironmental parameters on bacterial communities in offices finds that offices have city-specific bacterial communities, such that it can accurately predict which city an office microbiome sample is derived from, but office- specific bacterial communities are less apparent.
Obstetricians & Pediatricians: Cornerstone to Infant Gut microbiome Development
- Medicine
- 2015
The aim here is to provide obstetricians and pediatricians as well as other physician specialities with clinically relevant information regarding the development of fetal and infant gut microbiomes, fundamentals of gut microbiome dysbiosis which serves as the basis of many disease causations.
Individualization of pubic hair bacterial communities and the effects of storage time and temperature.
- Environmental ScienceForensic science international. Genetics
- 2017
Childhood Obesity: Immune Response and Nutritional Approaches
- Biology, MedicineFront. Immunol.
- 2015
Dietary intake of natural products endowed with anti-oxidant and anti-inflammatory activities may represent a valid interventional approach for preventing and/or attenuating the pathological consequences of obesity.
Long-term iron deficiency and iron supplementation exacerbate acute DSS-induced colitis and are associated with significant dysbiosis
- Medicine, BiologybioRxiv
- 2019
More work is needed to understand the impact of iron supplementation of the pathologenesis of IBD and rise that possiblity that the change in the microbiome, in patients with colitis, is a consequence of the increase in luminal iron and not simply the presence of colitis.
References
SHOWING 1-10 OF 10 REFERENCES
Human gut microbiome viewed across age and geography
- Biology, MedicineNature
- 2012
The need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization is underscored, as distinctive features of the functional maturation of the gut microbiome are evident in early infancy as well as adulthood.
Succession of microbial consortia in the developing infant gut microbiome
- BiologyProceedings of the National Academy of Sciences
- 2010
This study revealed that seemingly chaotic shifts in the microbiome are associated with life events; however, additional experiments ought to be conducted to assess how different infants respond to similar life events.
Moving pictures of the human microbiome
- BiologyGenome Biology
- 2011
The largest human microbiota time series analysis to date is presented, covering two individuals at four body sites over 396 timepoints and finds that despite stable differences between body sites and individuals, there is pronounced variability in an individual's microbiota across months, weeks and even days.
Temporal Dynamics of the Human Vaginal Microbiota
- MedicineScience Translational Medicine
- 2012
The temporal dynamics of the composition of vaginal bacterial communities in 32 reproductive-age women over a 16-week period revealed the dynamics of five major classes of bacterial communities and showed that some communities change markedly over short time periods, whereas others are relatively stable.
Diversity of the Human Intestinal Microbial Flora
- BiologyScience
- 2005
A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
Bacterial Community Variation in Human Body Habitats Across Space and Time
- Environmental ScienceScience
- 2009
The results indicate that the microbiota, although personalized, varies systematically across body habitats and time; such trends may ultimately reveal how microbiome changes cause or prevent disease.
Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
- Biology, MedicineScience
- 2013
Optimal responses to cancer therapy require an intact commensal microbiota that mediates its effects by modulating myeloid-derived cell functions in the tumor microenvironment, and disruption of the microbiota impairs the response of subcutaneous tumors to CpG-oligonucleotide immunotherapy and platinum chemotherapy.
Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice.
- BiologyCell host & microbe
- 2012
Exposure to environmental microorganisms and childhood asthma.
- MedicineThe New England journal of medicine
- 2011
Children living on farms had lower prevalences of asthma and atopy and were exposed to a greater variety of environmental microorganisms than the children in the reference group, and this exposure explains a substantial fraction of the inverse relation between asthma and growing up on a farm.
Forensic identification using skin bacterial communities
- BiologyProceedings of the National Academy of Sciences
- 2010
A series of studies introduces a forensics approach that could eventually be used to independently evaluate results obtained using more traditional forensic practices, and can use a high-throughput pyrosequencing-based approach to quantitatively compare the bacterial communities on objects and skin to match the object to the individual with a high degree of certainty.