The Human Leukocyte Antigen (HLA) System

@article{Shankarkumar2002TheHL,
  title={The Human Leukocyte Antigen (HLA) System},
  author={U. Shankarkumar},
  journal={International Journal of Human Genetics},
  year={2002},
  volume={4},
  pages={103 - 91}
}
  • U. Shankarkumar
  • Published 2002
  • Medicine, Biology
  • International Journal of Human Genetics
Abstract The discovery of Major Histocompatibility Complex (MHC) and its involvement in graft rejection, immune response and the genetic basis of disease associations lead to the birth of this new field of science called Immunogenetics. This field is important not only in basic biomedical research but also in clinical medicine. The growth of this field was further substantiated by the various International Histocompatibility Workshops. Solutions to idiopathic syndromes and autoimmune diseases… Expand
Clinical Role of Human Leukocyte Antigen in Health and Disease
  • Y. Mosaad
  • Biology, Medicine
  • Scandinavian journal of immunology
  • 2015
TLDR
Social behaviours are affected by HLA genes and preference for HLA disparate mates may provide ‘good genes’ for an individual's offspring, but the effects depend both on the genetic background and on the environmental conditions. Expand
HLA-KIR Interactions and Immunity to Viral Infections
TLDR
The aim of this review is focusing on the impact of HLA and KIR alleles and different combinations of these alleles on clinical outcome of viral diseases to validate this proof-of-concept with respect to the therapeutic interventions. Expand
HLA and Autoimmune Digestive Disease: A Clinically Oriented Review for Gastroenterologists
TLDR
The knowledge of current HLA nomenclature and of its association with some digestive diseases such as celiac disease can be useful in clinical practice for diagnostic and prognostic purposes and can avoid improper HLA typing. Expand
The Human Platelet and Leucocyte Antigens: Locations, Diagnosis and Solutions
  • Okolo RC, Ufelle SA, +4 authors Uchejeso OM
  • Medicine
  • 2020
TLDR
The most important function of the HLA molecule is in the induction, regulation of immune responses and in the selection of T cell repertoire, and subsets of HLA B27 and B57 are strongly associated with slow progression of acquired immunodeficiency syndrome (AIDS). Expand
Human Leukocyte HLA-B7 and HLA-B27 Antigen Typing amongHealthy Adults Primedwith HIV-1 DNA Boosted with RecombinantModified Vaccinia Ankara in Dar Es Salaam
TLDR
Evaluating the magnitude of Human leukocyte antigen production before and upon administration of multiclade, multigene HIV-1 DNA prime/MVA boost among healthy individuals in Dar es Salaam, Tanzania found no statistically significant difference in levels and recommended further HLA typing using molecular or cellular methods. Expand
Mutations in HLA DRB1*0101 exon 2 in a sub-population of Latvia.
TLDR
The results of the study are not complete in order to be able to say conclusively that the existing mutations in the exon 2 of HLA-DRB1 *01:01 gene cause wrong immune response, thus the protective functions of this allele are not fulfilled, and it is necessary to increase the study group. Expand
Kidney Transplantation: The Challenge of Human Leukocyte Antigen and Its Therapeutic Strategies
Kidney transplantation remains the treatment of choice for end-stage renal failure. When the immune system of the recipient recognizes the transplanted kidney as a foreign object, graft rejectionExpand
Do genetic factors play a role in the pathogenesis of diabetic microangiopathy?
TLDR
There is no direct and conclusive evidence that genetic factors play a role in the pathogenesis of microangiopathy in diabetes, but circumstantial evidence strongly suggest that genes do contribute to the susceptibility to small vessel disease. Expand
Host Gene Polymorphisms in Relation to Helicobacter Pylori Infection and Associated Diseases in a Population Based Cohort
TLDR
The IL1RN VNTR and the IL1β-31 alleles seem to be associated with intestinal metaplasia of the corpus mucosa and the grade of inflammation of the antrum, respectively. Expand
HLA molecules and nasal carriage of Staphylococcus aureus isolated from dialysis and kidney transplant patients at a hospital in Southern Brazil
TLDR
Investigation of the association between HLA class I and -B and class II molecules and nasal carriage of S. aureus in dialysis and kidney transplant patients in Southern Brazil suggests that HLA-DRB1*03 may be involved in susceptibility to nasal carriage in transplant patients. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 54 REFERENCES
Immunobiology of HLA
TLDR
The aim of this study was the localization and characterization of the specific residues of the HLA-A2 molecule that are recognized by B or T cells and the definition of serologic epitopes. Expand
Genetic basis of tuberculosis susceptibility in India.
TLDR
The factors that has been explored under Indian context in tuberculosis susceptibility are reviewed and an IL-10 associated disease susceptibility in HLAnon-DRB1*02, BCG scar negative, HLA high risk allele carrying individuals is identified, indicating that there may be several pathways leading to disease. Expand
HLA-DRB1*03 and DQB1*0302 associations in a subset of patients severely affected with systemic lupus erythematosus from western India
Genetic factors are likely to be important both in determining the overall susceptibility to systemic lupus erythematosus (SLE) and in influencing the remarkable clinical heterogeneity in diseaseExpand
The HLA system and its relation to disease.
TLDR
The associations of human diseases and particular HLA types have gone through a series of refinements as the nature of the major histocompatibility gene complex and its products has become better known and the possibility of applying this knowledge in prevention and even treatment of such autoimmune conditions as Graves' disease and type I diabetes is seen. Expand
Nomenclature for factors of the HLA system.
TLDR
A Nomenclature Committee composed of geneticists and immunologists, including specialists in tissue typing, has met after each of the Histocompatibility Workshops beginning with the Third Workshop in 1967 and met after the Sixth Workshop in Aarhus in July 1975. Expand
Distribution of HLA Antigens
TLDR
The more polymorphism used in the calculation of genetic distance, the more accurate the estimates of evolutionary relationship and the HLA system, which is highly polymorphic, can be used to further the authors' knowledge of evolutionary relationships. Expand
Evidence for novel DRB1*15 allele association among clinically definite multiple sclerosis patients from Mumbai, India.
TLDR
There is a complexity of the genetic susceptibility to MS in different populations studied and reported, and two novel alleles are revealed for the first time in MS patients that were hitherto unidentified from other parts of India and world as well. Expand
HLA Antigen Distribution in Selected Caste Groups from Mumbai, Maharastra, India
Abstract Indian population is well known for its genetic diversity. Among the numerous endogamous communities, which is restricted very much by custom, marriage and occupation, we have collected aExpand
Novel HLA Class I Alleles Associated with Indian Leprosy Patients
TLDR
It seems that HLA class I alleles play vital roles in disease association/pathogenesis with leprosy among Indians. Expand
DNA-RFLP analysis and genotyping of HLA-DR and DQ antigens.
TLDR
DNA-RFLP typing in genotypic selection of histocompatible donor-recipient pairs could potentially reduce many logistic problems in live-donor transplantation. Expand
...
1
2
3
4
5
...