Progress in Microbes and Molecular Biology
To better understand the essential components of the normal immune system, this review essentially aims to cover the current knowledge of individual components ofThe immune system and the important role of IRFs in regulating the immune system.
The Human Immune System toward Staphylococcus aureus
Overall, the immune reaction toward S. aureus contributes to stimulate innate and adaptive reactions and will be critical for the development of vaccines and novel therapies.
CDG and immune response: From bedside to bench and back
- Biology, MedicineJournal of inherited metabolic disease
Fostering research on glycoimmunology may elucidate the involved pathophysiological mechanisms and open new therapeutic avenues, thus improving CDG patients' quality of life.
Mesenchymal Stromal/Stem Cells-Derived Exosomes as an Antimicrobial Weapon for Orodental Infections
- Biology, MedicineFrontiers in Microbiology
Recently, it has been shown that cell-free therapies, like exosome therapies, by having more advantages than previous treatment methods are emerging as a promising strategy for the treatment of several diseases, in particular inflammatory conditions.
Viral ecosystem: An epidemiological hypothesis
- BiologyReviews in medical virology
The present review expresses the idea of the viral ecosystem and its importance, which has been supported in several studies and is assumed that the viruses have concentric zones, which its inner zone includes the most dangerous viruses for humans.
Fungal vaccines, mechanism of actions and immunology: A comprehensive review.
- Medicine, BiologyBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Potential targets for next generation antimicrobial glycoconjugate vaccines
- BiologyFEMS microbiology reviews
This review analyzes structural and functional differences of the polysaccharides exposed on the surface of emerging pathogenic bacteria, combined with medical need and technological feasibility of corresponding glycoconjugate vaccines.
Modeling Tumor Disease and Sepsis by Networks of Adaptively Coupled Phase Oscillators
- BiologyFrontiers in Network Physiology
It is shown that the complex cellular cooperation between parenchyma and stroma (immune layer) in the physiological and pathological case can be qualitatively and functionally described by a simple paradigmatic model of phase oscillators.
Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy
- Biology, MedicineJournal of immunology research
The current status of cancer immunotherapies, especially cancer vaccines, is summarized, the potential problems and solutions for the next breakthrough in cancer immunotherapy are discussed, and several issues remain to be solved to improve their clinical efficacy.
T-cell receptor excision circle levels and safety of paediatric immunization: A population-based self-controlled case series analysis
- MedicineHuman vaccines & immunotherapeutics
No association between newborn T-cell receptor excision circle levels and subsequent health services utilization events following DTa-IPV-Hib, Pneu-C-13, and meningitis C vaccinations are identified, providing further support for the safety of pediatric vaccinations.
SHOWING 1-10 OF 107 REFERENCES
B cell superantigens: a microbe’s answer to innate-like B cells and natural antibodies
- Biology, MedicineSpringer Seminars in Immunopathology
This work has characterized a class of microbial product with highly adapted binding interactions with host immunoglobulins/B cell receptors (BCRs), which enable the targeting of large supra-clonal sets of B cells for activation-associated apoptotic death.
Regulatory T Cells: Differentiation and Function
- Biology, MedicineCancer Immunology Research
Regulatory T cells expressing the X chromosome–linked transcription factor Foxp3 suppress inflammatory responses in diverse biological settings and serve as a vital mechanism of negative regulation of immune-mediated inflammation.
Evolution of Innate Immunity: Clues from Invertebrates via Fish to Mammals
- BiologyFront. Immunol.
The high specificity, antibody maturation, immunological memory, and secondary responses of adaptive immunity were so successful that it allowed higher vertebrates to reduce the number of variants of the innate molecules originating from both invertebrates and lower vertebrates.
Innate or Adaptive Immunity? The Example of Natural Killer Cells
NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development.
Microorganisms and their interaction with the immune system
- BiologyJournal of leukocyte biology
Understanding the different mechanisms by which microorganisms interact with the immune system can impact the design of live vaccines as well as the development of novel therapeutic immunomodulators that can provide medicine with powerful new tools to manage immune disorders, allograft rejection, remote multiple organ failure resulting from trauma, autoimmune diseases, etc.
Recognition of pathogens and activation of immune responses in Drosophila and horseshoe crab innate immunity.
Toll-like receptors and innate immunity
- BiologyJournal of Molecular Medicine
This review focuses on the functions of PRRs in innate immunity and their downstream signaling cascades and identifies cytoplasmic PRRs to detect pathogens that have invaded cytosols.
Complement activation, regulation, and molecular basis for complement‐related diseases
- BiologyThe EMBO journal
An integrated and updated view of complement is presented based on structural and functional data and the new roles attributed to complement are described and the structural and mechanistic understanding of the complement system rationalizes the genetic defects conferring uncontrolled activation or other undesirable effects of complement.