The Human Genetic History of the Americas: The Final Frontier

@article{ORourke2010TheHG,
  title={The Human Genetic History of the Americas: The Final Frontier},
  author={Dennis H O'Rourke and Jennifer A. Raff},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={R202-R207}
}
The Americas, the last continents to be entered by modern humans, were colonized during the late Pleistocene via a land bridge across what is now the Bering strait. However, the timing and nature of the initial colonization events remain contentious. The Asian origin of the earliest Americans has been amply established by numerous classical marker studies of the mid-twentieth century. More recently, mtDNA sequences, Y-chromosome and autosomal marker studies have provided a higher level of… Expand

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References

SHOWING 1-10 OF 54 REFERENCES
Mitochondrial DNA and Y chromosome diversity and the peopling of the Americas: Evolutionary and demographic evidence
  • T. Schurr, S. Sherry
  • Geography, Medicine
  • American journal of human biology : the official journal of the Human Biology Council
  • 2004
TLDR
A second expansion that perhaps coincided with the opening of the ice‐free corridor probably brought mtDNA haplogroup X and NRY haplogroups P‐M45b, C‐M130, and R1a1‐M17 to North and Central America. Expand
Colonization Models and Initial Genetic Diversity in the Americas
  • A. Fix
  • Geography, Medicine
  • Human biology
  • 2002
TLDR
The mode and tempo of colonization of the Americas established the initial pattern of continental genetic diversity and generated multiple founder effects leading to extreme loss of genetic variation among Native Americans. Expand
The Peopling of the New World: Perspectives from Molecular Anthropology
▪ Abstract A number of important insights into the peopling of the New World have been gained through molecular genetic studies of Siberian and Native American populations. These data indicate thatExpand
Mitochondrial population genomics supports a single pre-Clovis origin with a coastal route for the peopling of the Americas.
TLDR
It is shown, by using 86 complete mitochondrial genomes, that all Native American haplogroups, including haplogroup X, were part of a single founding population, thereby refuting multiple-migration models and supporting a pre-Clovis occupation of the New World. Expand
Origin and evolution of Native American mtDNA variation: a reappraisal.
TLDR
Reappraising mtDNA control region sequences from aboriginal Siberians and Native Americans confirms in agreement with linguistic, archaeological and climatic evidence that the major wave of migration brought one population, ancestral to the Amerinds, from northeastern Siberia to America 20,000-25,000 years ago. Expand
Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas.
TLDR
This individual's mitochondrial DNA represents the founder haplotype of an additional subhaplogroup of haplogroup D that was brought to the Americas, demonstrating that widely held assumptions about the genetic composition of the earliest Americans are incorrect. Expand
Y-chromosome evidence for differing ancient demographic histories in the Americas.
TLDR
Age estimates based on Y-chromosome microsatellite diversity place the initial settlement of the American continent at approximately 14,000 years ago, in relative agreement with the age of well-established archaeological evidence. Expand
The crucial role of calibration in molecular date estimates for the peopling of the Americas.
TLDR
There appears to be little support for an American colonization event significantly antedating the earliest physical evidence of human occupation, according to closer examination of the calibration techniques involved. Expand
A Three-Stage Colonization Model for the Peopling of the Americas
TLDR
A model for the peopling of the New World in which Amerind ancestors diverged from the Asian gene pool prior to 40,000 years ago and experienced a gradual population expansion as they moved into Beringia is supported. Expand
Diversity and age of the four major mtDNA haplogroups, and their implications for the peopling of the New World.
TLDR
The results put the peopling of the Americas clearly in an early, pre-Clovis time frame, extending the results initially found for haplogroup A to the three other major groups of mtDNA sequences found in the Americas. Expand
...
1
2
3
4
5
...