The Human EKC/KEOPS Complex Is Recruited to Cullin2 Ubiquitin Ligases by the Human Tumour Antigen PRAME

Abstract

The human tumour antigen PRAME (preferentially expressed antigen in melanoma) is frequently overexpressed during oncogenesis, and high PRAME levels are associated with poor clinical outcome in a variety of cancers. However, the molecular pathways in which PRAME is implicated are not well understood. We recently characterized PRAME as a BC-box subunit of a… (More)
DOI: 10.1371/journal.pone.0042822

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@inproceedings{Costessi2012TheHE, title={The Human EKC/KEOPS Complex Is Recruited to Cullin2 Ubiquitin Ligases by the Human Tumour Antigen PRAME}, author={Adalberto Costessi and Nawel Mahrour and Vikram Sharma and Rieka Stunnenberg and Marieke A. Stoel and Esther Tijchon and Joan W Conaway and Ronald C. Conaway and Hendrik G. Stunnenberg}, booktitle={PloS one}, year={2012} }