The Human Bone Morphogenetic Protein 4 (BMP-4) Gene: Molecular Structure and Transcriptional Regulation

  title={The Human Bone Morphogenetic Protein 4 (BMP-4) Gene: Molecular Structure and Transcriptional Regulation},
  author={E. M. Shore and M.-q. Xu and P. Shah and H. B. Janoff and G. Hahn and M. A. Deardorff and L. Sovinsky and N. B. Spinner and M. A. Zasloff and J. M. Wozney and F. Kaplan},
  journal={Calcified Tissue International},
  • E. M. Shore, M.-q. Xu, +8 authors F. Kaplan
  • Published 1998
  • Biology, Medicine
  • Calcified Tissue International
  • Bone morphogenetic protein 4 (BMP-4) is a vital regulatory molecule that functions throughout human development in mesoderm induction, tooth development, limb formation, bone induction, and fracture repair and is overexpressed in patients who have fibrodysplasia ossificans progressiva. The human gene encoding bone morphogenetic protein 4 (BMP-4) has been isolated and its structural organization characterized. The complete DNA sequence of an 11.2 kb region has been determined. BMP-4 mRNA is… CONTINUE READING
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