The Human Antimicrobial Peptide LL-37, but Not the Mouse Ortholog, mCRAMP, Can Stimulate Signaling by Poly(I:C) through a FPRL1-dependent Pathway*

@article{Singh2013TheHA,
  title={The Human Antimicrobial Peptide LL-37, but Not the Mouse Ortholog, mCRAMP, Can Stimulate Signaling by Poly(I:C) through a FPRL1-dependent Pathway*},
  author={Divyendu Singh and R. Qi and J. Jordan and L. S. San Mateo and C. Kao},
  journal={The Journal of Biological Chemistry},
  year={2013},
  volume={288},
  pages={8258 - 8268}
}
Background: How the cathelicidin LL-37 enhances Toll-like receptor 3 signaling is poorly understood. Results: We determined that LL-37-poly(I:C) complex can localize to early endosomes with TLR3 through the FPRL1 receptor, whereas poly(I:C) localizes to endosomes by a different mechanism. Conclusion: Double-stranded RNAs can localize with TLR3 by multiple trafficking pathways. Significance: This work establishes a mechanism for cross-talk between LL-37, double-stranded RNA, and TLR3. LL-37 is… Expand
LL-37 Peptide Enhancement of Signal Transduction by Toll-like Receptor 3 Is Regulated by pH
Cathelicidins Modulate TLR-Activation and Inflammation
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