The Hsp90 molecular chaperone complex regulates maltose induction and stability of the Saccharomyces MAL gene transcription activator Mal63p.

@article{Bali2003TheHM,
  title={The Hsp90 molecular chaperone complex regulates maltose induction and stability of the Saccharomyces MAL gene transcription activator Mal63p.},
  author={Mehtap Bali and Bin Zhang and Kevin A Morano and Corinne A. Michels},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 48},
  pages={47441-8}
}
Induction of the Saccharomyces MAL structural genes encoding maltose permease and maltase requires the MAL activator, a DNA-binding transcription activator. Genetic analysis of MAL activator mutations suggested that protein folding and stability play an important role in MAL activator regulation and led us to explore the role of the Hsp90 molecular chaperone complex in the regulation of the MAL activator. Strains carrying mutations in genes encoding components of the Hsp90 chaperone complex… CONTINUE READING

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