The Hsp90 chaperone as a promising drug target.

@article{Piper2001TheHC,
  title={The Hsp90 chaperone as a promising drug target.},
  author={Peter W Piper},
  journal={Current opinion in investigational drugs},
  year={2001},
  volume={2 11},
  pages={1606-10}
}
  • Peter W Piper
  • Published 2001 in Current opinion in investigational drugs
Geldanamycin and radicicol, antibiotics produced by Streptomycetes and fungi, respectively, were originally discovered many years ago. Only recently was it discovered that they bind with high specificity within the ADP/ATP binding pocket of the Hsp90 molecular chaperone, thereby inhibiting the function of Hsp90. In eukaryotic cells Hsp90 catalyzes the final activation step of many of the most important regulatory proteins. Cells that lose this function are severely compromised and cannot… CONTINUE READING

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