The Hrs/STAM complex in the downregulation of receptor tyrosine kinases.

@article{Komada2005TheHC,
  title={The Hrs/STAM complex in the downregulation of receptor tyrosine kinases.},
  author={Masayuki Komada and Naomi Kitamura},
  journal={Journal of biochemistry},
  year={2005},
  volume={137 1},
  pages={1-8}
}
Cell surface receptor proteins that have undergone endocytosis are transported to the endosome. From the endosome, ligand-activated receptor tyrosine kinases are further transported to the lysosome for degradation, a process called "receptor downregulation." By contrast, nutrient receptors, such as those for low-density lipoprotein and transferrin, are recycled back to the plasma membrane. Sorting of these two types of receptors occurs at the endosome, where ubiquitination of receptor proteins… CONTINUE READING

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