The Hormonal Profile of Norethindrone Acetate: Rationale for Add-Back Therapy With Gonadotropin-Releasing Hormone Agonists in Women With Endometriosis

@article{Chwalisz2012TheHP,
  title={The Hormonal Profile of Norethindrone Acetate: Rationale for Add-Back Therapy With Gonadotropin-Releasing Hormone Agonists in Women With Endometriosis},
  author={Kristof Chwalisz and Eric S. Surrey and Frank Z. Stanczyk},
  journal={Reproductive Sciences},
  year={2012},
  volume={19},
  pages={563 - 571}
}
Gonadotropin-releasing hormone agonists (GnRHa) are an effective treatment of endometriosis-associated pelvic pain. The use of hormonal add-back therapy can alleviate the hypoestrogenic symptoms associated with GnRHa therapy, while preserving therapeutic efficacy. Norethindrone acetate (NETA) is a unique progestin that has both estrogenic and androgenic properties and is effective as an add-back regimen without estrogen supplementation. Through its estrogenic activity, NETA exerts beneficial… Expand
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TLDR
The impact of GnRH analogues on both bone loss and fracture risk as well as describe different add-back regimens are explored. Expand
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TLDR
There is a place for GnRH antagonists in the management of symptomatic endometriosis and clinical trials should be conducted, taking into account the different phenotypes in order to propose novel algorithms. Expand
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