The Hop2 protein has a direct role in promoting interhomolog interactions during mouse meiosis.

@article{Petukhova2003TheHP,
  title={The Hop2 protein has a direct role in promoting interhomolog interactions during mouse meiosis.},
  author={Galina V. Petukhova and Peter J. Romanienko and R. Daniel Camerini-Otero},
  journal={Developmental cell},
  year={2003},
  volume={5 6},
  pages={927-36}
}
The S. cerevisiae Hop2 protein and its fission yeast homolog Meu13 are required for proper homologous chromosome pairing and recombination during meiosis. The mechanism of this requirement is, however, not understood. The previous studies in Saccharomyces suggested that Hop2 is a guardian of meiotic chromosome synapsis with the ability to prevent or resolve deleterious associations between nonhomologous chromosomes. We have generated a Hop2 knockout mouse that shows profound meiotic defects… CONTINUE READING