The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination

@article{Petukhova2005TheHA,
  title={The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination},
  author={Galina V. Petukhova and Roberto J Pezza and Filip Vanevski and Mickael J-Y Ploquin and J Masson and R. Daniel Camerini-Otero},
  journal={Nature Structural &Molecular Biology},
  year={2005},
  volume={12},
  pages={449-453}
}
During the first meiotic division, homologous chromosomes (homologs) have to separate to opposite poles of the cell to ensure the right complement in the progeny. Homologous recombination provides a mechanism for a genome-wide homology search and physical linkage among the homologs before their orderly segregation. Rad51 and Dmc1 recombinases are the major players in these processes. Disruption of meiosis-specific HOP2 or MND1 genes leads to severe defects in homologous synapsis and an early… CONTINUE READING
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