The Hop-Like Stress-Induced Protein 1 Cochaperone Is a Novel Cell-Intrinsic Restriction Factor for Mitochondrial Tombusvirus Replication

@article{Xu2014TheHS,
  title={The Hop-Like Stress-Induced Protein 1 Cochaperone Is a Novel Cell-Intrinsic Restriction Factor for Mitochondrial Tombusvirus Replication},
  author={K. Xu and Jing-Yi Lin and P. Nagy},
  journal={Journal of Virology},
  year={2014},
  volume={88},
  pages={9361 - 9378}
}
  • K. Xu, Jing-Yi Lin, P. Nagy
  • Published 2014
  • Biology, Medicine
  • Journal of Virology
  • ABSTRACT Recent genome-wide screens reveal that the host cells express an arsenal of proteins that inhibit replication of plus-stranded RNA viruses by functioning as cell-intrinsic restriction factors of viral infections. One group of cell-intrinsic restriction factors against tombusviruses contains tetratricopeptide repeat (TPR) domains that directly interact with the viral replication proteins. In this paper, we find that the TPR domain-containing Hop-like stress-inducible protein 1 (Sti1p… CONTINUE READING
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