The Homeostasis of Plasmodium falciparum-Infected Red Blood Cells

  title={The Homeostasis of Plasmodium falciparum-Infected Red Blood Cells},
  author={Jakob M. A. Mauritz and Alessandro Esposito and Hagai Ginsburg and Clemens F. Kaminski and Teresa Tiffert and Virgilio L. Lew},
  journal={PLoS Computational Biology},
  pages={455 - 463}
The asexual reproduction cycle of Plasmodium falciparum, the parasite responsible for severe malaria, occurs within red blood cells. A merozoite invades a red cell in the circulation, develops and multiplies, and after about 48 hours ruptures the host cell, releasing 15-32 merozoites ready to invade new red blood cells. During this cycle, the parasite increases the host cell permeability so much that when similar permeabilization was simulated on uninfected red cells, lysis occurred before… CONTINUE READING