The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells

@article{Mitsui2003TheHN,
  title={The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells},
  author={K. Mitsui and Y. Tokuzawa and Hiroaki Itoh and K. Segawa and M. Murakami and Kazutoshi Takahashi and Masayoshi Maruyama and M. Maeda and S. Yamanaka},
  journal={Cell},
  year={2003},
  volume={113},
  pages={631-642}
}
Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts grow infinitely while maintaining pluripotency. Leukemia inhibitory factor (LIF) can maintain self-renewal of mouse ES cells through activation of Stat3. However, LIF/Stat3 is dispensable for maintenance of ICM and human ES cells, suggesting that the pathway is not fundamental for pluripotency. In search of a critical factor(s) that underlies pluripotency in both ICM and ES cells, we performed in silico differential… Expand
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